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Sunday, February 27, 2011

HEART REPAIR ITSELF







From left. Eric Olson, Hesham A Sadek and Enzo Porrello.
Until now we only had knowledge that many fish and amphibians regenerate their damaged hearts themselves throughout his life without scarring involved. Hesham A Sadek (University of Texas. Department of Molecular Biology, Southwestern Medical Center) and his team have managed to get the damaged heart of a newborn mammal to fully itself repair as long as the damage (removal of cardiac apex), were conducted in the first 7 days, showing histological analysis in these cases the generation of an intense proliferation of cardiomyocytes -derived from existing- with minimal hypertrophy or fibrosis, distinguishing it from an adult repair process. Echocardiography performed 2 months later showed that mouse regenerated apex had normal systolic function. Self-regeneration is lost if the damage is done 7 days after the birth of the mouse, giving rise instead to heart failure. Possibility is open to repair itself congenital heart defects in human newborns and also in adults using a few genes and/or drug-activating genes.

CORAZONES AUTOREPARADOS

Hasta hoy solo se tenia conocimiento que muchos peces y anfibios auto-regeneran a lo largo de su vida sus corazones dañados, sin cicatrices de por medio. Hesham A Sadek (University of Texas. Department of Molecular Biology, Southwestern Medical Center) y su equipo han logrado que el corazon dañado de un mamifero recien nacido se autorepare completamente siempre y cuando el daño (remoción del ápex cardiaco), se realice en los primeros 7 dias, demostrando el análisis histológico en estos casos la generación de una intensa proliferación de cardiomiocitos -derivados de los existentes- con minima hipertrofia o fibrosis, distinguiéndose de un proceso de reparación adulto. La ecocardiografia realizada 2 meses después demostró que el ápex regenerado del raton tenia función sistólica normal. La autoregeneracion se pierde si el daño se realiza 7 dias después de nacido el raton, generándose en estos casos insuficiencia cardiaca. Abriendose la posibilidad de autoreparar defectos cardiacos congenitos en neonatos humanos y porque no también en adultos empleando unos pocos genes y/o drogas activadoras de genes.

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