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Sunday, May 15, 2011

NATURAL REGENERATION OF THE HEAD



Studies in planarians (Schmidtea mediterranean/small flatworm), settle the concept that living organisms are the embodiment of bio-software contained in their respective DNAs. If before surprised us the regeneration of the tail of a lizard or the missing of an axolotl, today is not surprising given the regeneration of the head of a planarian in just 7 days. You lose your head but not the computer bio-program contained in any of thousands of regenerative stem cells know as neoblasts, widely distributed in the body of planarians. Peter Reddie (Whitehead Institute for Biomedical Research in Cambridge/Massachusetts), has discovered the role of neoblasts in the regeneration of planarian heads. For his part, Daniel Wagner after irradiating and killing of all neoblasts of a planarian demonstrated how a single transplanted c-neoblast was capable of regenerating the body of a lethally irradiated planaria. Completing the circle, Petersen and Reddien demonstrated that Wnt signal molecule decided to regenerate the head or tail loss. After an injury Wnt molecule promotes the regeneration of the tail unless it is inhibited by another protein molecule: Notum, then form the head. If the molecule Notum in turn is inhibited by RNA interference (RNAi), the tail regenerates.




REGENERACION NATURAL DE LA CABEZA

Estudios realizados en planarias (Schmidtea mediterranea/pequeño gusano), sedimentan el concepto de que los organismos vivientes son la materialización de bio-programas informaticos contenidos en sus respectivos ADNs. Si antes sorprendia la regeneración de la cola de una lagartija o el miembro perdido de un axolote, hoy no sorprende ya, la regeneración de la cabeza de una planaria en apenas 7 dias. Se pierde la cabeza pero no el programa informatico contenido en cualquiera de miles de células pluripotenciales regenerativas : neoblastos, ampliamente distribuidos en el soma de las planarias.

Peter Reddie (Whitehead Institute for Biomedical Research in Cambridge/Massachusetts), ha descubierto el rol de los neoblastos en la regeneracion de la cabeza de las planarias. Por su lado, Daniel Wagner tras irradiar y matar a todos los neoblastos de una planaria demostró como un solo c-neoblasto trasplantado fue capaz de regenerar a la planaria irradiada letalmente. Completando el circulo, Petersen y Reddien demostraron que la molecula señal Wnt decidia la fomacion de la cabeza o cola perdida. Despues de una injuria la molecula Wnt promueve la regeneracion de la cola excepto si es inhibida por otra molecula proteica : Notum, formándose en tal caso la cabeza. Si la molecula Notum a su vez es inhibida por RNA de interferencia (RNAi), se regenera la cola.

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