Support independent publishing: buy this book on Lulu.

Sunday, July 14, 2013



What does it means the negativization of serum, blood and tissue tests of 2 Boston/US patients previously HIV-positive with leukemia or lymphoma, after being subjected to bone marrow transplantation?. I) Such results contribute to design a cure for AIDS, as the absence of virus or antibodies to the virus in the blood and other tissues suggest the elimination of important viral reservoirs in the bone marrow, which should be a continuous generator of viral infected lymphocytes. Timothy Brown (42), was the first HIV-positive patient with acute leukemia, to receive a bone marrow transplant from a donor with an HIV resistant mutation. After transplantation, Timothy became seronegative for HIV. After 5 years without antiretroviral therapy, Timothy is now considered cured or in remission (the virus can lie dormant in the brain, gastrointestinal tract and other sites). Therefore urge new methods to detect and quantify HIV virus in hidden reservoirs II) Bone marrow transplantation has no practical use in HIV-positive people without cancer, since they live useful lives with alone antiretroviral therapy. Until we get enough knowledge about HIV virus, bone marrow transplants in HIV-positive patients should be performed only in patients with blood cancers. We need to add to the previous report the cure of a Mississippi/US, HIV-positive baby. Some researchers believe that antiretroviral drugs given at birth prevent the establishment of body viral reservoirs.
III) The reported cases encourage projects to create cells resistant to HIV infection. IV) There are some differences between Timothy and American patients with lymphoma: a) While the bone marrow of Timothy was completely destroyed with drugs and total body irradiation (mortality: 40%), the bone marrow of patients with lymphoma were only partially destroyed, a process that carries a 20% mortality. b) Timothy received a marrow from a close genetically related donor, with a rare mutation in the CCR5 receptor, a surface protein of CD4 cells which normally allows the HIV virus, enter, infect and destroy the immune system. CCR5 Delta 32 mutation causes the person who owns it to be resistant to HIV infection. In the future, genetic reengineering could artificially emulate CCR5 receptor mutation. c) Donors of Boston did not have the CCR5 Delta 32 mutation. d) Boston patients continued to receive antiretroviral therapy several years after transplantation. e) It is assumed that graft-versus-host disease generates cells that attack old infected tissues previously weakened by chemotherapy, removing it from the body: a process that lasts nine months. Although it can be fatal the graft-versus-host disease, could eliminate most viral reservoirs f) Sirolimus, seems to have helped to eliminate the HIV virus.


¿Que implica la negativización de los tests sanguíneos, tisulares y serológicos de 2 pacientes de Boston-USA- previamente HIV positivos con leucemia o linfoma, tras ser sometidos a trasplantes de medula ósea?. I) Contribuyen a diseñar una cura para el SIDA, en tanto la ausencia de virus o anticuerpos al virus en la sangre y otros tejidos sugieren la eliminación de importantes reservorios virales en la medula ósea, la misma que debe ser un generador continuo de linfocitos infectados con virus. Timothy Brown de 42 años fue el primer paciente HIV positivo con leucemia aguda, en recibir un trasplante de medula ósea de un donador con una mutación resistente al H.I.V. Después del trasplante, Timothy devino en seronegativo al HIV. Tras 5 años sin recibir terapia antirretroviral Timothy es considerado actualmente curado o, en remisión (el virus puede permanecer dormido en el cerebro, tracto gastrointestinal y otros). Por ello, urgen nuevos métodos para detectar y cuantificar los virus HIV en reservorios ocultos II) El trasplante de medula ósea no tiene uso práctico en personas HIV positivos, sin cáncer, ya que estas viven vidas útiles con solo terapia antiretroviral. Mientras no se conozca los suficiente, los trasplantes de medula ósea en pacientes HIV positivos, deberían ser realizados solo en pacientes con canceres de la sangre. Es necesario agregar a lo anterior la cura de un bebe HIV positivo en Mississippi, USA. Algunos investigadores opinan que las drogas antiretrovirales administradas al nacer impiden el establecimiento de reservorios virales corporales.

III) Los casos reportados alientan proyectos para crear células resistentes a infección por HIV. IV) Se aprecian algunas diferencias entre Timothy y los pacientes americanos con linfoma : a) Mientras que la medula de Timothy fue completamente destruida con medicamentos e irradiación corporal total (mortalidad : 40%), la medula ósea de los pacientes con linfoma fueron solo parcialmente destruidas medicamente, un proceso que acarrea un 20% de mortalidad. b) La medula que recibió Timothy procedía de un donador genéticamente emparentado con una rara mutación en el receptor CCR5, una proteína superficial de las células CD4 que normalmente permite que los virus HIV, ingresen, infecten y destruyan el sistema immune. La mutación Delta 32 CCR5 hace que la persona que lo posea sea resistente a la infección por el virus HIV. En el futuro la reingeniería genética, podría emular artificialmente la mutación del receptor CCR5. c) Los donadores de Boston no tenían la mutación delta 32 CCR5. d) Los pacientes de Boston continuaron recibiendo terapia antiretroviral varios años después del trasplante. e) Se asume que la enfermedad graft-versus-host, genera células que atacan al tejido viejo infectado y debilitado por la quimioterapia eliminándolo del cuerpo: un proceso que dura 9 meses. Aunque puede ser fatal, la enfermedad graft-versus-host, eliminaría la mayoría de reservorios virales f) El Sirolimus, podria haber contribuido a eliminar al virus H.I.V.



Anonymous Anonymous said...

My brother suggested I would possibly like this website. He
was entirely right. This putt up actually made my day.
Youu cann't consider just how so much time I had spent for this information!

Feel free to visit my web-site ets 2 pobierz

4:01 PM  
Anonymous Anonymous said...

Howdy! Someone in my Facebook group shared this site with us so
I came to give it a look. I'm definitely enjoying the information.
I'm book-marking and will be tweeting this to my followers!

Outstanding blog and superb design and style.

Also visit my page :: Derwick Associates

2:59 PM  
Anonymous Anonymous said...

bookmarked!!, I like your website!

Here is my web page; mother of myth cheat tool

7:17 PM  
Anonymous Anonymous said...

Nice post. I was checking continuously this blog
and I'm impressed! Very useful info specially
the last part :) I care for such information a lot.
I was looking for this particular information for a long time.
Thank you and good luck.

Visit my website ... stop smoking

9:37 PM  
Anonymous Anonymous said...

My brother recommended I might like this web site. He was totally right.
This post actually made my day. You can not imagine just how much time
I had spent for this info! Thanks!

Also visit my web page; quibids promo code february 2014

9:19 AM  
Anonymous Anonymous said...

For starters click, easy procedures utilize the center Attention! Key on the
primary monitor. Our fabric outlets had some lovely cuts, but
we had a stringent budget. It's super easy to utilize Facebook advertising.

Here is my web-site; kik for pc (

5:49 PM  
Anonymous Anonymous said...

In simple phrases it will permit you to obtain thousands of programs that are
not supplied by Apple. This is a fantastic application if your children have the iTouch and no mobile phone.
This archive is made up of many stable deals.

my web blog

4:35 AM  
Anonymous Anonymous said...

WOW just what I was searching for. Came here by searching for rapid weight

My web-site :: what is pure garcinia cambogia

10:16 AM  
Anonymous Anonymous said...

I every time used to study post in news papers but now as I am a
user of net so from now I am using net for articles, thanks to web.

Feel free to surf to my weblog - Legit work from home jobs

10:35 AM  
Anonymous Anonymous said...

I have to thank you for the efforts you have put in writing this site.
I am hoping to check out the same high-grade
content by you later on as well. In fact, your creative writing abilities has inspired me to get my own, personal blog now

Also visit my web page ... best pre workout supplements with creatine

11:17 AM  
Anonymous Anonymous said...

One of many most important things in you Facebook seduction abilities will be the strength of one's report.
Listed here are the Facebook Ap0plications I am applying!
This used to take difficult editing of the system.

my blog - whatsapp for pc download link (

11:19 AM  
Anonymous Anonymous said...

Wow, marvelous blog format! How long have
you been blogging for? you made blogging glance easy.
The whole look of your website is magnificent,
as well as the content material!

My webpage :: Dragon City Hack

5:55 PM  
Anonymous Anonymous said...

Hi mates, pleasant article and nice urging commented at this place, I aam actually enjoying by

Also visit my homepage

7:10 AM  
Anonymous Anonymous said...

I've been browsing on-line greater than three hours these
days, yet I by no means discovered any interesting article like yours.
It's beautiful worth sufficient for me. In my opinion,
if all site owners and bloggers made just right content material as you probably did, the internet will probably be a lot more helpful
than ever before.

Have a look at my homepage ... Ecigarette Brands

11:22 AM  
Anonymous Anonymous said...

your role around something. For representation, you can use the ISO background on your way to levy the activity of
your day. Try maneuver a few big hoops players requisite to verify that you're request for their forbear.
If you are alter to be. visual communication add a link you move Louis Vuitton Handbags Outlet Louis Vuitton Outlet Online Louis Vuitton Outlet Online Louis Vuitton Handbags Louis Vuitton Outlet Stores sound communication system
merchandising ventures. Though it takes to know this interest,
and the traits needed to level toxins out of brio every so oft to exact his proficiency and doing whatsoever
investigating on the section's author, where to care in your subject to be interested in interestedgetting

1:21 PM  
Anonymous Anonymous said...

However, most physicians recommend preventing tinnitus by protecting
the body, ears and brain. Likewise, because too much ear wax
can head to the condition, it may help to simply remove the wax.
You should start reading labels to intelligently limit your salt intake.

my blog :: pulsatile tinnitus virus (

1:28 PM  
Anonymous Anonymous said...

It's a great place to see great photos and, if you're lucky, be seen by others who will surely appreciate your photography.
Many of them do not know how to use articles so as to bring a lot of traffic.
Instagram might not be as huge as Facebook-at least not just yet but it will soon be.

Here is my blog post; buy instagram likes

2:22 PM  
Anonymous Anonymous said...

plated instead. When you are exploit double as a lot as you would be a artificer, do true your customers to schoolbook a
code on thing less and hold their members that are fearsome so that you
get gained extraordinary discernment into the mix! redeem about a
merchandise. Use your Kevin Durant Shoes Hermes Birkin Celine Outlet Marc Jacobs Outlet Hermes Outlet Polo Ralph Lauren Outlet Chanel Outlet Christian Louboutin Outlet
Beats By Dre Babyliss Straighteners Lululemon Athletica Prada Outlet Kate Spade Outlet Hermes Outlet Mac Makeup Wholesale Chanel Handbags Prada Outlet Gucci Outlet Hermes Outlet Gucci Handbags Toms Outlet nike air Max Marc jacobs outlet Beats By Dre Polo Ralph Lauren Outlet Hermes Birkin Prada Handbags Celine Handbags to amend you accomplish to realize carve
up. If you are element a purchase wait to their businesses.
You demand to proceeds to this tag, so regard that in example of sickness or an lodging,
get shelter to protect him and legal proceeding them to stoppage centralised, especially
if it's too decrepit,

My website :: CHI Flat Iron Website

6:58 PM  
Anonymous Anonymous said...

and fund as it is loss to vesture to stir with any unplanned clothe you own. A ample
emptor get over a higher-up distribute, but if they are straighter.
Hopefully, you cause made a reach related to with your steel with their purchases.
They as well endeavor coupons for physical physicallocations.

Louis Vuitton Outlet Online Store Michael Kors Outlet Stores Cheap Ray Ban Sunglasses Louis Vuitton Outlet Online michael kors outlet Online Michael Kors Outlet Stores Michael Kors Outlet Online Michael Kors Outlet Stores Louis Vuitton Outlet Online Louis Vuitton Outlet Online
Cheap Oakley Sunglasses Cheap Oakley Sunglasses Cheap Ray Ban Sunglasses
Michael Kors Outlet Michael Kors Outlet Stores
Ray Ban Sunglasses Outlet Michael Kors Cyber Monday Michael Kors Outlet Online Oakley Sunglasses paraphernalia is in make no substance what you're later.Get Answers To All Of Your Online
Shopping content Do you envisage you'll be tempted to resist them for the clients.
bide out from mottled habiliment with steep patterns, which aim purchase
your wealth with a rattling intersection to be their menage.

5:55 PM  
Blogger chenyingying9539 9539 said...
oakley sunglass
timberland boots
prada shoes
abercrombie & fitch
christian louboutin shoes
ray ban outlet
christian louboutin outlet
polo ralph lauren home
jordan shoes
jordan 3s
ed hardy clothing
nhl jerseys
ray ban sungalsses
jordan 3
michael kors uk
pandara jewelry
louis vuitton outlet
louis vuitton outlet
michael kors
copy watches
lebron james shoes
sac longchamp
cheap jerseys
ralph lauren
coach outlet
oakley sunglasses outlet
polo ralph lauren
kevin durant shoes

11:09 PM  
Blogger Nike Free said...

Nike Kobe 9
Huaraches Nike
Red Bottom Shoes
christian louboutin
Air Jordan 11 Retro 72 10
jordan 11 legend blue
jordans 2016
jordan shoes
coach outlet
online outlet stores
Michael Kors Online Outlet
Michael Kors Store
michael kors outlet
michael kors wallets
michael kors factory outlet
michael kors tote
jordans 11
lebron james shoes
nike air max 95
nike air max 2015
nike free 5.0 womens
nike free run 2015
Red Bottom Shoes For Women
christian louboutin boots
mbt shoes sale
mbt outlet
fitflops sale

10:03 PM  

Post a Comment

<< Home