COVID, A THEORY II

A COVID-19,  THEORY  II

1-Asked about the reasons for medical consultations of patients critically affected by Covid-19, who survived  after being hospitalized in the Intensive Care Unit (ICU), the American cardiologist: Harlan Krumholz (Yale, University), answered to -The Los AngelesTimes (10.04.20), that the signs and symptoms of convalescents did not correspond to a disease confined to the respiratory system, but rather to a severe bodily injury induced by a severe hypoxemia that included cardiac, liver, kidney, brain, endocrine and hematopoietic complications. 2-After observing Peruvians and Ecuadorians die suddenly in the streets, we think the same. Although the attack begins in the respiratory sphere, at a certain point the viral attack becomes systemic very quickly. Appreciation supported by a report from The Sun newspaper (20.04.20), where it is reported that two, 42-year-old Chinese doctors, who after having been critically ill by Covid-19, in Wuhan since 18.01.20, received life support with: Extracorporeal Membrane Oxygenation: ECMO: (extracorporeal blood oxygenation, replacing the heart and lung).https://www.youtube.com/watch?v=FiETnE4as5M&t=3s. During convalescence, some systemic effects became more visible: extensive darkening of the skin in exposed areas, attributed to viral liver damage or side effects of some medication. Convalescent physicians say they will improve as their livers self-repair, condition that we think need to rule out a acquired hemochromatosis, induced by difficulties in iron metabolism, requiring a liver biopsy and dosing of serum iron, transport capacity. iron, ferritin, etc. 3) A rapid systemic bodily attack associated with an increase in dyspnea should have as a logic allied to the blood stream. In the previous post, we discussed the possible pathogenesis induced by Covid-19, based on the theoretical bioinformatics work of Chinese researchers Wenzhong Liu and Hualan Li (Sichuan University): Covid-19: Attacks the 1-Beta Chain of Hemoglobin andcaptures the Porphyrin to Inhibit Human Heme Metabolism, ChemRxiv. Preprint, who based on virus homologies with certain structural characteristics of the human heme, suppose an initial anchorage of viral glycoproteins to the porphyrins that contain the heme, forcing the uncoupling of ferrous iron, which being  spilled into the bloodstream would prevent the transport of O₂  and CO₂, generated  adverse systemic effects and a cytokine storm, in response. 4) Now, another article, many conferences, testimonies of benefited people and the visualization -with a phase contrast microscope- of the reversal of agglutinated methemoglobinemic blood to oxygenated blood, using chlorine dioxide (ClO₂), the same that achieves a fast increasing  O₂ saturation demonstrated by gasometry, reversing the chemical-structural damage induced by Covid-19 to porphyrins. That is the theory of the German biophysicist Andreas Kalcker: https://lbry.tv/@Kalcker:7/Porque-ClO2-funciona-para-Covid-19: who proposes the use of Cl dioxide (ClO₂), in aqueous or intravenous form at a pH of 7.4, at concentrations of 50 ppm, to reverse the hypoxemic effects of Covid-19. By preventing ClO₂ from disrupting porphyrins, it would also be shown that the viral attack is not focused on the lungs, but it is directed against the beta  chain of Hb, inducing systemic effects that limit the normal transport of 0₂ and CO₂, generating chemical pneumonitis causing ground glass lung images, when free iron is poured into the blood, affecting  the liver. In a minefield where what is known is little, we communicate this theory, associated with some facts that need further verification. It would be very useful to perform   in patients admitted to the Intensive Care Unit  -who are being helped by mechanical ventilators- : liver biopsies and dose plasma pyrroles, bilirubins, reticulocytes, transaminases, iron, EPO, transferrin, ferritin, and methemoglobin. Based on the above, we believe that the most suitable method to treat Covid-19 hypoxemia is extracorporeal oxygenation (ECMO), which is more effective than mechanical ventilators.