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Thursday, June 09, 2011


Paul Riley (University College London's Institute of Child Health), has managed to regenerate heart cells of mice with myocardial infarction induced by arterial clamping, turning special cells of the epicardium into cardiac muscle cells, which were integrated into the existing heart cells. A process carried out routinely in embrionic state, but impossible in the adult. Ability reactivated in mice using protein tβ4 (thymosin β4). used in healthy and diseased mice to convert epicardial cells in other tissues. It was also observed that the infarct scar size was reduced significantly and the cardiac performance of mice improved. is thought to be useful in early stages of heart attacks in humans. If given within the first hour post-infarct it would prevent great harm. It is thought Tβ4 will be useful as a preventive measure for people at high risk (high blood pressure, high cholesterol, genetic or family disposition). Although posr-infarction patients now live longer, the survival imply great suffering. We conclude that the best treatment for heart attack is the reactivation of dormant stem cells from infarcted hearts.


Paul Riley (University College London's Institute of Child Health), ha logrado regenerar células cardiacas de ratones con infarto de miocardio inducido por clampeo arterial, transformando celulas especiales del epicardio en celulas musculares cardiacas, que se integraron a las células existentes del corazón. Un proceso llevado a cabo rutinariamente en estado embrioanrio, pero imposible en el estado adulto. Habilidad reactivada en ratones usando la proteína tβ4 (thymosin β4). empleada en ratones saludables y enfermos para convertir células epicardicas en otros tejidos. Se observo asimismo que la cicatriz del infarto se redujo de tamaño significativamente mejorando la performance de los ratones. Se piensa que la tβ4 sera de utilidad en estadios tempranos de ataques cardiacos en humanos. Si se administrase durante la primera hora post-infarto se evitaría un gran daño. Se piensa será de utilidad en forma preventiva para personas de alto riesgo (presion alta, colesterol elevado, disposicion genética o familiar). Aunque los pacientes posr-infarto viven mas en la actualidad, sobreviven con gran sufrimiento. Se concluye que el mejor tratamiento para el infarto cardiaco es la reactivación de células madre dormidas del propio corazón infartado.



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