Bad controlled diabetes and brain

BRAIN, DIET and DIABETES

In some way, the type of food eaten by humans is related to the functions of our organs, our general corporality and our state of mind. According to the Australian researcher Felice Jacka, https://www.youtube.com/watch?v=vCAzzhOg-xk, the children (1 1/2-5 years), of pregnant women who consumed junk food (high fat and abundant sugar),  turned out to be more aggressive, prone to tantrums and at the same time more fearful. However, the type of food eaten is not only related to the mentioned changes. Recently, the researcher Lilianne R. Mujica-Parodi (Stony Brooks Universityy/Lab for Computational Neurodiagnostics) and collaborators, https://doi.org/10.1073/pnas.1913042117 investigated whether the type of  ingested diet was capable of optimally maintaining the functionality of the brain neural networks, improving neural functional communication, when the dietary fuel (usually glucose) is exchanged for ketones, being recognized  ever since: the optimal functionality of neural networks, as a biomarker of brain aging. Previous studies have shown that the destabilization of the brain neural networks conditions a decrease in brain activity and cognitive acuity, effect being noted from the age of 47, with more rapid destabilization from the age of 60. DOI: https: //doi.org/ 10.1016 / S2213-8587 (13) 70192-X. In the case of type 2 diabetics (DM2), with insulin resistance, the possibility has been raised that glucose elevation (poorly controlled), is an early risk factor for dementia in adulthood due to rapid decrease in memory, reasoning and cognition doi: 10.1212 / WNL.0b013e3181f25f06, so some researchers think that dementia might even be a metabolic disease. To demonstrate  the influence of diet type on optimal maintenance of the functionality of brain neural networks required using large-scale functional magnetic resonance datasets and scanning a cohort provided with a standard diet, night fast, and ketogenic diet and another independent cohort, with overnight fasting before and after administration of an exogenous bolus of ketone ester (D-β-hydroxybutyrate), equal in calories to that provided by a type of diet based   in glucose. In this study, the functionality of human brain neural networks was destabilized by glucose and stabilized by ketone, regardless of whether ketosis was achieved with a ketogenic diet or exogenous ketone esters, the results suggesting that destabilization of neural networks  may reflect early signs of hypometabolism associated with dementia due to persistent glucose elevation, as occurs in uncontrolled DM2, indicating that the destabilization of neural networks could be an adaptive response of the brain in order to conserve energy in the face of scarcity of resources. This study clarifies how diet influences brain aging, explaining how insulin resistance in poorly controlled diabetics accelerates the progression of cognitive decline as people age. A deterioration possibly related to hypometabolism of brain glucose, reversed by another type of ketone-based diet, which by increasing the available energy, prevent early brain aging. Young people who eat mainly junk food could be another group of beneficiaries, provided they switch to diets containing polyunsaturated fatty acids: fat from certain fish, vegetable oils, nuts, seeds, etc.