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Thursday, September 28, 2006

Early human embryos : dead or alive?.

http://www.youtube.com/watch?v=SbGlZmr--as

Video: Tim Russert challenges White House chief of staff Josh Bolten on the Bush administration's inconsistent views of stem cell research.

Video Explanation in Spanish : Tim Russert, pasa un video en el cual un vocero de la Casa Blanca asegura que el Presidente Bush, considera las investigaciones con celulas madre embrionarias humanas, un crimen porque destruyen los embriones. Para Bush, un huevo fertilizado es un ser humano, por lotanto no dara dinero federal para actividades que destruiran embriones humanos. Russert arguye, porque entonces no se prohiben las practicas de fertilizacion in vitro, que extraen celulas a los embriones humanos, para diagnosticar alteraciones genéticas. Bolten, afirma que ese es otro tema y que los cientificos deberian investigar alternativas al empleo de celulas madre embrionarias, por ejemplo celulas madre de individuos adultos.

A team of scientists led by the Serbian biologist Miodrag Stojkovic (MS), researcher of Center FSC Biology of the University of Newcastle, the Prince Felipe Research Center of Valencia/Spain and Syntocell (Serbian Center of investigation of Stem Cell), have been able to obtain cellular lines of human embryonic Stem Cell (hESC), coming from human early embryos, with detainee processes of cellular division (technically dead). According to MS, 2/3 of the human embryos generated in : in vitro fertilization clinics (IVF), don't reach at least the blastocyst stage (12-24 cells), being discarded. In one article appeared yesterday in Stem Cells, is reported that human embryos with detainee cellular division, are donated regularly by the in vitro fertilization clinics, to the University of Newcastle, for investigation ends.

Of this material (161, human embryos), MS and collaborators, studied in way special : 13 embryos with detainee cellular division, among 6-7 days after the fertilization, counting with among 16-24 cells. MS and collaborators considered dead to the embryos whose detainee cellular division, remained unaffected during 48 hours, proceeding after it to cultivate them. Of 13 carried out cultivations, 5 were successful. Of these, 2 gave healthy stem cell lines. At the end one SC line took place in vitro and in vivo, the 3 usual germinal layers of a human being. As it is known the method of generation of SC lines from alive human embryos, are rejected by religious and ethical groups to consider that the techniques, destroy the embryos. 1 month ago Advanced Cell Technology of California designed an obtaining method of stem cells lines starting from a cell, extirpated of an embryo of 8 cells, allowing that the 7 remaining cells completed its development generating a complete human being. The procedure fell in discredit because it destroyed embryos.The topic here is: are the embryos with detainee cellular division dead? What valid do they have the established approaches, to consider dead to a human embryo?

Embriones humanos tempranos :vivos o muertos?.

Un equipo de cientificos liderados por el biólogo serbio Miodrag Stojkovic (MS), investigador del Center FSC Biology de la Universidad de Newcastle, el Principe Felipe Research Center de Valencia/España y Syntocell (centro serbio de investigación de células madre), han logrado obtener lineas celulares de células madre embrionarias humanas (cMEH), procedentes de embriones humanos tempranos, con procesos de división celular detenida (técnicamente muertos). Según MS, 2/3 de los embriones humanos generados en las clinicas de fertilización in vitro (IVF), no alcanzan siquiera el estadio de blastocisto (12-24 celulas), siendo descartados. En el articulo aparecido ayer en Stem Cells magazine, se detalla que los embriones humanos con división celular detenida, son donados regularmente por las clinicas de fertilización in vitro, a la Universidad de Newcastle, para fines de investigación.

De este material (161 embriones humanos), MS y colaboradores, estudiaron de modo especial 13 embriones con división celular detenida espontáneamente, entre los 6-7 dias despues de la fertilización, contando con entre 16-24 células. MS y colaboradores consideraron muertos a los embriones cuya detención de su división celular, permanecia inalterada durante 48 hs, procediendo trás ello a cultivarlos. De 13 cultivos realizados, 5 fueon exitosos. De estos, se obtuvieron 2 lineas celulares de células madre, de las cuales una, produjo in vitro y en vivo, las 3 capas germinativas usuales de un ser humano. Como se sabe las células madre obtenidas de embriones humanos in vivo, son rechazadas por grupos religiosos y éticos por considerar que las técnicas para su obtención, destruyen los embriones. Hace 1 mes Adanced Cell Technology de California diseñó un método de obtención de lineas de celulas madre a partir de una célula, extirpada de un embrión de 8 células, permitiendo que las 7 células restantes completaran su desarrollo generando un ser humano completo. El procedimiento cayó en desprestigio porque destruia embriones.El tema aquí es : ¿estan muertos los embriones con división celular detenida? ¿Qué validéz tienen los criterios establecidos, para considerar muerto a 1 embrión humano?

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