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Thursday, July 12, 2007

AND NOW, WE HAVE EMBRYOIDS.


The severe regulatory controls that George Bush has implanted in USA against the indiscriminate employment of stem cells coming from human embryos, is forcing the inventive of many American scientists with the purpose of generating something similar to embryonic stem cells, without infringing the law. In this way, researchers of Lifeline Cell Technology/Maryland, (Click :Cloning and Stem Cells Scientific paper), have developed a method that induced parthenogenetic activation (using FSH, gonadoliberina and hCG), in a non-fertilized egg (parthenogenetic human embryonic stem cell: phESC), stimulating it to generate an embryoid (or blastocyst, morfologically equal to usual stem cells, 46 XX, usual F. Alkaline and telomerasa activity, appropiate markers, differentiated derivatives of all 3 germinal layers, that give embryoids in suspension cultures and teratomas in inmunodeficient animals), from which embryonic stem cells (hESC), are extracted. For it, ES Rezanova, NA Turovets, Jeffrey Janus et al, used oocytes coming from 5 sterile women. The work that for the first time is carried out in human beings is genetically a significant step in matching transplants tissues. It doesn't work in men. The study appears in the Journal Cloning and Stem Cells (Vol. 3.Number : 9). Kent Vrana, of the Pennsylvania State University that has carried out similar works in monkeys, assures that the aim is to create stem cells genetically compatible between donor and host and not to create babys. The advance suggests that some day a woman that wants a transplant to treat her diabetes or an affection of her spine could donate eggs to a laboratory that would create tissues that her body would not reject (histocompatible cell-based cell therapy).

George Daley, a scientist of Harvard Stem Cell Institute, said that these, are variants of embryonic stem cells coming from something different to a normal embryo. Not yet we know if these cells, will be as good as those coming from fertilized mature embryos. It exists the possibility that father's lack will deteriorate the performance of these new stem cells. The DNA of the sperm carries particular markers that differ from those carried out in an oocyte’s DNA, being affected the activity of specific genes. For Ronald M. Green, ethicist of Dartmouth College, the processes are ethically acceptable, as long as a human being are not developed and embryos are not destroyed. Nevertheless, the opposition centers their critics against any type of embryonic stem cells producer of specialized tissues, because the process always finishes generating and destroying embryos. The reverend Tad Pacholczyk, of the National Catholic Bioethics Center in Philadelphia, says: if these organized cells growths forming embryos (in the first days and then they stop), they are always human of short life, therefore these embryos should not be created for then to be destroyed.

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3 Comments:

Anonymous tumay said...

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4:57 PM  
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