Friday, November 30, 2007

FOUNTAIN of YOUTH: A STEP CLOSER


The recent nuclear cell reprogramming from differentiated to stem cells in a single mouse, has opened significant collateral avenues. The advance of a paper online, to be published in Genes and Development (Howard Y. Chang, et al: Motif module map reveals enforcement of aging by continual NF- B activity. Dec. 15 2007; 21-24/Program in Epithelial Biology and Cancer Biology/School of Medicine/Stanford University), accounting for the reversal of the effects of ageing in the skin of a 2 years mouse, that acquired the same genetic profile that a newborn mouse, after blocking the action of the protein NF-k/beta, suggests 2 things. I) that individual cells and human body in general, are biological Turing machines (scheduled for live forever and not, the 120 years usual). II) That the hostile environment, prevents the continuous action, of this marvelous biological machine. That meanwhile, it will be sufficient in the next future, to reprogram our cells every so often, to live much more. Chang, who like other scientists, consider ageing as an illness, suggests that this last is a consequence of changes in specific genes, but that the result of wear for use and reuse. III) The process of forming pluricelular organisms with subsequent cell differentiation (various types of cells and organs, through silencing or persistence of original genes), created a complex brain, but lost body vitality. It would be necessary at this time, to create a theory (the way of a periodic table), explaining the sequential formation of the various bodily organs of complex organisms, beginning from the influence of basic genes.


CONSECUENCIAS DE DIFERENCIACION y DESDIFERENCIACION GENETICA.


La reciente reprogramación nuclear de células diferenciadas a células madre, de un mismo ratón, apertura importantes avenidas colaterales. El avance de un paper online, a ser publicado en Genes and Development (Howard Y. Chang, et al : Motif module map reveals enforcement of aging by continual NF- B activity. Dec 15 2007; 21-24/Program in Epithelial Biology and Cancer Biology/School of Medicine/Stanford University), dando cuenta de la reversión de los efectos de la vejéz, en la piel de ratones de 2 años, que adquirieron el mismo perfil genético que un ratón recién nacido , trás bloquear la acción de la proteina NF-k/beta, sugiere 2 cosas. I) que las células individuales y el cuerpo humano en general, son máquinas biológicas de Turing (programadas para vivir eternamente y no, los 120 años usuales). II) Que el medio ambiente hostil, impide la acción continua, de esta formidable máquina biológica. Que en el futuro cercano, bastaria con reprogramar nuestras células cada cierto tiempo, para vivir mucho más. Chang, que al igual que otros cientificos, estiman a la vejéz como una enfermedad, sugiere que esta es consecuencia de cambios en genes especificos, mas que el resultado del desgaste por uso y reuso. III) Que el proceso de formación de organismos pluricelulares con ulteriores diferenciaciones celulares (diversos tipos celulares y órganos, mediante apagamiento o persistencia de genes primigenios), creó un cerebro complejo, pero perdió en vitalidad corporal. Seria necesario de momento, crear una teoria (al modo de una tabla periódica), que explique la formación secuencial de los distintos organos corporales de organismos complejos, partiendo del set básico portado por las células madre.

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