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Wednesday, September 30, 2009

SIRTUINS and RESVERATROL




The British gerontologist Aubrey de Gray and transhumanists has scored a major victory influencing researcher’s mind of Harvard Medical School proffesors to produce chemicals designed to prolong health and extended life span. David Sinclair and Christoph Westphal cofounders of Sitris Pharmaceuticals, manufacture drugs that mimic resveratrol, a chemicalpresent in certain wines, grapes, wine, oysters, peanuts, walnuts, endowed with antioxidant, longevity and anti-cancer cells properties. These scientists are engaged also in drug discovery that triggers genes sirtuins (silent information regulator two (Sir2) proteins), activity responsible for cellular regulation in fungi and involved in regulation of aging, apoptosis and stress resistance.

The effect of sirtuins emulates those achieved in mice that consuming 30% less calories (caloric restriction), live 40% more, avoiding degenerative diseases of aging. Sirtuins in small doses are more potent than resveratrol. Administered to mice are effective against lung cancer, colon cancer, melanoma, lymphoma, type-2 diabetes, cardiovascular disease and Alzheimer's disease. They also reduce inflammation and lack of side effects. The classical theory of aging is based on the deleterious effect of mutations in DNA. Today, it is assumed that aging can be reversed because mutations are not direct causes of aging.
SIRTUINAS y RESVERATROL

El gerontólogo británico Aubrey de Grey y la mayoría de transhumanistas acaban de anotarse una victoria importante al influir en investigadores de la Facultad de Medicina de Harvard a fabricar químicos tendientes a prolongar la salud y años de vida. David Sinclair y Christoph Westphal cofundadores de Sitris Pharmaceuticals, fabrican yá medicamentos que imitan al resveratrol un químico presente en algunos vinos, uvas, mosto, ostras, mani, nueces, dotado de propiedades antioxidantes, y anticancerígenas que prolongan la longevidad célular. Estos científicos también están empeñados en descubrir medicamentos activadores de los genes de las sirtuinas (silent information regulator two (Sir2) proteins), responsables de la regulación celular en hongos e implicado en la regulación del envejecimiento, apoptosis y resistencia al estrés.
El efecto de las sirtuinas emula al logrado en ratones que consumiendo 30% menos calorías (restricción calórica), viven 40% más, evitando enfermedades degenerativas propias del envejecimiento. Las sirtuinas a pequeñas dosis son más potentes que el resveratrol. Administradas a ratones son efectivas contra cancer de pulmon, de colon, melanoma, linfoma, diabetes tipo-2, enfermedad cardiovascular y enfermedad de Alzheimer. También reducen la inflamación y carecen de efectos colaterales. La teoría clásica del envejecimiento aludía al efecto deletéreo de mutaciones en el DNA. Hoy, se asume que el envejecimiento puede ser revertido porque las mutaciones no son causas directas del envejecimiento.

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