ANTIAGING THERAPIES ARE COMING
SCIENTIFIC BREAKTROUGH OF THE
YEAR
For their implications and
perspectives, the Dunedin study performed
by researchers from Duke
University (Durham), Otago (New Zealand), California (USA) and London King
Collegue that validated biological age
markers in a cohort of young adults, showed that
some of them were aging more slowly and others more quickly, opens the door to
the use of anti-aging therapies (rapamycin and others -successfully employed in
experimental animals-), in humans since youth, being expected that they can slow aging, lengthen human lifespan and globally decrease the
morbidity of late old age. If anti-aging therapies work in humans, the
assertion charged to Aubrey de Grey and others who argue that death is a
disease and as such can and should be treated will be valid. Dunedin (New
Zealand city from where people were recruited) study examined 954 young people
(with the same chronological initial age), with 18 physiological biomarkers
(HbA1C, cardiorespiratory fitness, waist-hip ratio, FEV1/FVC, FEV1, mean blood
pressure, telomere length of leukocyte, BMI, creatinine clearance, urea, lipoproteins,
triglycerides, dental health, total cholesterol, white blood cell count, hsCRP,
hdl cholesterol, apoB100/apo A1), in 3 points: 26, 32 and 38 years of age,
validating two methods by which old age can be measured in young adults, one
cross-sectional and other longitudinal, allowing the latter, a quantification
of the rate of physiological deterioration in multiple organ systems (lung,
periodontal, cardiovascular, renal, hepatic and immune function). These methods
were employed in young biological age that still had not developed age-related
diseases. At the end of the study (38 years), the biological age varied between
28-61 years, that’s to say, biomarkers of biological age changed over time
and were different in each individual studied. Individuals that aged quickly were less
physically able, showed cognitive decline and brain aging and looked older. The
biological age measured in young people could be used to identify and assess
causes of aging and rejuvenating therapies.
ACONTECIMIENTO CIENTÍFICO DEL AÑO
Por sus implicancias y perspectivas, el estudio realizado por investigadores de la
Universidades de Duke (Durham), Otago
(New Zeland), California (USA) y el King
Collegue de Londres, al validar marcadores de edad biológica en una cohorte de
adultos jóvenes que mostró que algunos de ellos envejecían más lentamente y otros más rápido,
abre las puertas al empleo de terapias antienvejecimiento (rapamicina y otros; empleadas
con éxito, en animales de experimentación), a ser empleadas en humanos
desde la juventud, esperándose enlentecer
el envejecimiento, alargar la vida útil humana
y disminuir la morbilidad de la vejez tardía a nivel global. Si las terapias antienvejecimiento funcionan en
humanos, cobrara validez el aserto
de Aubrey de Grey y otros, que sostienen que la muerte
es una enfermedad y que como tal puede y debe tratarse. El estudio Dunedin (ciudad
neozelandesa de donde procedían las personas), examino a 954 jóvenes (con la misma edad cronológica inicial),
con 18 biomarcadores fisiológicos (HbA1C,
funcionalidad cardiorespiratoria, relación cintura-cadera, FEV1/FVC, FEV1,
media de la presión arterial, longitud del telomero de los leucocitos, BMI, depuración
de creatinina, urea, lipoproteínas, triglicéridos, salud dental, colesterol
total, cuenta de glóbulos blancos, hsCRP, colesterol hdl, apoB100/apoA1), en 3 puntos : 26, 32 y 38 años de edad, validándose 2 métodos con los que
la vejez
puede ser medida en adultos jóvenes, uno seccional-cruzado y otro longitudinal, permitiendo este último,
una cuantificación de la velocidad del deterioro fisiológico
en múltiples órganos y sistemas (pulmonar, periodontal, cardiovascular, renal,
hepático y funcionalidad inmune). Estos métodos
valoraron la vejez biológica en jóvenes
que aun no habían desarrollado enfermedades relacionadas con la vejez. Al finalizar
el estudio (38 años), la edad biológica vario
entre 28 a 61 años, es decir que los
biomarcadores de edad biológica cambiaron
con el tiempo y fueron diferentes en cada individuo estudiado. Los individuos que
envejecían rápidamente se mostraron físicamente menos
capaces, mostraron declinación cognitiva y envejecimiento cerebral y lucían más viejos. La edad biológica medida
en jóvenes podría ser empleada usada para identificar causas de envejecimiento
y evaluar terapias rejuvenecedoras.
Labels: antiageing medications, biological age markers, dubedim study, rapamycin
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