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Thursday, July 09, 2015

ANTIAGING THERAPIES ARE COMING




SCIENTIFIC BREAKTROUGH OF THE YEAR

For their implications and perspectives, the Dunedin study performed   by researchers from   Duke University (Durham), Otago (New Zealand), California (USA) and London King Collegue that validated  biological age markers in a cohort of young adults,   showed  that some of them were aging more slowly and others more quickly, opens the door to the use of anti-aging therapies (rapamycin and others -successfully employed in experimental animals-), in humans since youth,  being expected  that they can  slow aging, lengthen human lifespan and globally  decrease the  morbidity of late old age. If anti-aging therapies work in humans, the assertion charged to Aubrey de Grey and others who argue that death is a disease and as such can and should be treated will be valid. Dunedin (New Zealand city from where people were recruited) study examined 954 young people (with the same chronological initial age), with 18 physiological biomarkers (HbA1C, cardiorespiratory fitness, waist-hip ratio, FEV1/FVC, FEV1, mean blood pressure, telomere length of leukocyte, BMI, creatinine clearance, urea, lipoproteins, triglycerides, dental health, total cholesterol, white blood cell count, hsCRP, hdl cholesterol, apoB100/apo A1), in 3 points: 26, 32 and 38 years of age, validating two methods by which old age can be measured in young adults, one cross-sectional and other longitudinal, allowing the latter, a quantification of the rate of physiological deterioration in multiple organ systems (lung, periodontal, cardiovascular, renal, hepatic and immune function). These methods were employed in young biological age that still had not developed age-related diseases. At the end of the study (38 years), the biological age varied between 28-61 years, that’s to say,   biomarkers of biological age changed over time and were different in each individual studied. Individuals that aged quickly were   less physically able, showed cognitive decline and brain aging and looked older. The biological age measured in young people could be used to identify and assess causes of aging and rejuvenating therapies.

ACONTECIMIENTO CIENTÍFICO DEL AÑO

Por sus implicancias y perspectivas, el   estudio realizado por investigadores de la Universidades de Duke (Durham),   Otago (New Zeland),  California (USA) y el King Collegue de Londres, al validar   marcadores de edad biológica en una cohorte de adultos jóvenes que mostró que algunos de ellos   envejecían más lentamente y otros más rápido, abre  las puertas al empleo de terapias  antienvejecimiento (rapamicina y otros; empleadas con éxito, en animales de experimentación), a ser empleadas   en humanos desde la juventud, esperándose  enlentecer el envejecimiento,  alargar la vida útil humana y disminuir la morbilidad de la vejez tardía a nivel global. Si  las terapias antienvejecimiento funcionan en humanos, cobrara validez  el aserto de  Aubrey de Grey y otros,  que  sostienen que la   muerte es una enfermedad y que como tal puede y debe tratarse.   El estudio Dunedin (ciudad neozelandesa de donde procedían las personas),  examino a   954 jóvenes (con la misma edad cronológica inicial), con  18 biomarcadores fisiológicos (HbA1C, funcionalidad cardiorespiratoria, relación cintura-cadera, FEV1/FVC, FEV1, media de la presión arterial, longitud del telomero de los leucocitos, BMI, depuración de creatinina, urea, lipoproteínas, triglicéridos, salud dental, colesterol total, cuenta de glóbulos blancos, hsCRP,  colesterol hdl, apoB100/apoA1), en 3 puntos :  26, 32 y 38 años de edad, validándose  2 métodos con  los  que  la vejez  puede ser medida en adultos jóvenes, uno  seccional-cruzado  y otro longitudinal, permitiendo este   último, una   cuantificación de la velocidad del deterioro fisiológico en múltiples órganos y sistemas  (pulmonar, periodontal, cardiovascular, renal, hepático y funcionalidad inmune). Estos métodos  valoraron  la vejez biológica en jóvenes que aun no habían desarrollado enfermedades relacionadas con la vejez. Al finalizar el estudio (38 años),  la edad biológica vario entre 28 a 61 años, es decir  que los biomarcadores de edad biológica  cambiaron con el tiempo y fueron diferentes en cada individuo estudiado. Los individuos que  envejecían  rápidamente se mostraron físicamente menos capaces, mostraron declinación cognitiva y envejecimiento cerebral  y lucían más viejos. La edad biológica medida en jóvenes podría ser empleada usada para identificar causas de envejecimiento y evaluar terapias rejuvenecedoras.

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5 Comments:

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