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Sunday, December 02, 2007


We don't know if for strategy: Shinya Yamanaka, decided to publish a recent paper (Generation of induced pluripotent stem cells without Myc genes from mouse and human fibroblasts), because being already signed up in the Gladstone Institute Cardiovascular of Disease/San Francisco or, because their biological visions, are delineated so perfectly that he is able to execute scientific investigations, quickly. One of the critics made to his previous work (published hardly 10 days ago in Cell Online), was that one of the 4 genes (Myc +), inserted in differentiated skin fibroblasts of mice (to reprogram them toward stem cells : iPS), was implied in several cancer types. Reacting quickly, Yamanaka carried out the same experience, obviating the insertion of the gene Myc +, obtaining viable stem cells : Myc-negative iPS. According to own comments, the technique although overcomes the previous one, in security, lost in efficiency (minor numbers of stem cells). Nevertheless, the method opens the route to generation of human tissues to scale, without tissue rejections and without ethical objections.

Celulas madre reprogramadas, sin efectos tumorales

No sabemos si por estrategia : Shinya Yamanaka, decidió publicar un reciente paper (Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts), estando ya enrolado en el Gladstone Institute of Cardiovascular Disease/San Francisco o, porque sus cosmovisiones biológicas, estan tan perfectamente delineadas que es capáz de ejecutar investigaciones científicas, con rapidez. Una de las criticas hechas a su anterior trabajo (publicado hace apenas 10 dias en Cell Online), fué que uno de los 4 genes (Myc +), insertados en fibroblastos diferenciados de piel de ratones (para reprogramarlos hacia células madre:iPS), estaba implicado en varios tipos de cáncer. Ni corto no perezozo, Yamanaka realizó la misma experiencia, obviando la inserción del gene Myc +, obteniendo celulas madre viables: Myc-negative iPS. Según comentarios propios, la técnica aunque supera en seguridad a la anterior, perdio en eficiencia (menor numero de células madre). No obstante, el método abre el camino a la generacion de tejidos humanos a escala, sin rechazos tisulares y sin objeciones éticas de por medio.



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