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Tuesday, October 13, 2009

MOTHER PASS LEUKEMIA TO HER UNBORN CHILD


Mel Greaves and his team at the Institute of Cancer Research, have discovered something scary, but at the same time promising. There would be some rare cases (17 of leukemia and melanoma in last 100 years) of cancer transmission from sick mothers to their children, in utero. By Advanced genetic fingerprinting technique, they showed that leukemic clones of mother and child shared the same genomic sequences of BCR-ABL1 fusion, single cell origin label. Although in theory the child's immune system should block and stop cancer cells from crossing the placenta, these developed a larger deletion in one copy of chromosome 6p including deletion of HLA alleles, making it impossible for the child's immune system to recognizes them as foreign, leading to new types of treatment to first heal and then protect by vaccination from certain cancers.


MADRE Y FETO CON LEUCEMIA

Mel Greaves y su equipo del Institute of Cancer Research, han descubierto algo terrorifico, pero al mismo tiempo prometedor. Existirían algunos raros casos (17 de leucemia y melanoma en ultimos 100 años), de trasmisión de cáncer de madres enfermas a sus hijos, in utero. Mediante la tecnica Advanced genetic fingerprinting, demostraron que los clones leucémicos de madre y niño compartían las mismas secuencias de fusión genómica BCR-ABL1, etiqueta de origen único celular. Aunque en teoría el sistema immune del niño deberia bloquear e impedir que las células cancerosas crucen la placenta, estas desarrollaron una deleción mayor en una copia de su cromosoma 6p incluyendo deleción de alelos HLA, haciendo imposible que el sistema inmune del niño las reconozca como extrañas, lo que llevaria a nuevos tipos de tratamiento, para primero curar y después protegernos mediante vacunas de ciertos canceres.

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