Friday, January 13, 2012

SYNTHETIC WINDPIPE TRANSPLANT


It has just performed at a hospital in Sweden, the second operation for replacement of the natural windpipe of a 30 year old man who suffered from an inoperable cancer by aother synthetic manufactured with nano-fibers of plastic called PET, commonly used in soda bottles, subsequently seeded with stem cells coming from bone marrow. The leader of this process: Paolo Macchiarini (Advanced Center for Translational Regenerative Medicine/Karolinska Institute/Stockholm), has made this process before using tracheae of deceased persons. The patient who is recovering favorably is clearly a cyborg. Now, it is expected to use resorbable plastics to build these synthetic scaffolds. Then, this become a routine procedure..

The artificial trachea was placed in a bioreactor containing stem cells in solution. 2 days after, the artificial trachea was sutured to the throat and lungs of the patient. According to David Green (Harvard Bioscience) who designed the bioreactor, the stem cells were divided to produce cartilage. Green says that was necessary to add to the bioreactor transcriptional factors to force stem cells to differentiate into specific tissues of the trachea. Apparently a series of chemical signals produced by the body of the patient facilitated the success of this transplantation. The synthetic scaffold was designed using CT scans of the nayural trachea for obtaining exact copies.


TRASPLANTE  SINTETICO  DE  TRAQUEA
Se acaba de realizar en un hospital de Suecia la segunda operación de reemplazo de la tráquea natural de un hombre de 30 años que padecía un cáncer inoperable por otra sintética manufacturada con nano-fibras de un plástico :PET, empleado comúnmente en botellas de soda, ulteriormente sembrado con células madre procedentes de su médula ósea. El líder de este proceso: Paolo Macchiarini (Advanced Center for Translational Regenerative Medicine/Karolinska Institute/Stockholm), ha realizado este proceso anteriormente empleando tráqueas de personas fallecidas. El paciente que se recupera favorablemente es a todas luces un cyborg. Ahora solo falta que se empleen plásticos reabsorbibles como matriz de soporte para que el procedimiento sea rutina.

La tráquea artificial fué colocada en un bioreactor que contenía células madre en solución. 2 días después la tráquea artificial fué suturada a la garganta y pulmones del paciente. Según David Green (Harvard Bioscience) que diseñó el bioreactor, las células madre se dividieron y produjeron cartílago. Green añadió que fué necesario añadir al bioreactor factores de transcripcción para forzar a las células madre a diferenciarse en tejidos específicos de la tráquea. Al parecer una serie de señales químicas producidas por el propio cuerpo del paciente facilitaron el éxito del trasplante. La matriz de soporte fué diseñada empleando imágenes CT scans de la tráquea existente para obtener copias exactas.

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