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Wednesday, August 26, 2020



Jacobo Grinberg Zylberbaum (1946- 1994?), was a neurophysiologist with Jewish roots, born in Mexico, where he was professor of Neurophysiology at the National University of Mexico (UNAM) in which, he had contact with Mexican shamans, especially those from Sonora (Llaquis) and with a Mexican woman: Pachita (Bárbara Guerrero, a  psychic surgeon), to whom he dedicate a book (Los Shamanes de México. Pachita. A truthful testimony of the mind over the body. Ed. Heptada, Madrid, 1990), for allowing him to participate in her healing practices from which, due to the extraordinary scenes he saw, he deduced the participation in them of  a neural plane (of the Mexican shaman), on human matter and the underlying space. When Grinberg describes the surgical practices performed by Pachita as amazing, for making them appear out of nowhere: diseased kidneys that were  replaced with healthy ones in seconds, or  damaged cerebral cortices that in seconds were replaced by  healthy cerebral cortices that also appeared instantly out of nowhere, leaving in the end the affected patients :healthy. After analyzing the scientific bases of Pachita's psychic surgeries, Grinberg imitated her procedures for a year, concluding that Pachita's healing ability was the result of the interaction of two realities: a functioning neural field around the shamans' brains  and an environmental spatio-temporal network (Grinberg-Zylberbaum, J. (1997). Ideas About a New Psychophysiology of Consciousness: The Syntergic Theory. The Journal of Mind and Behavior, 18 (4), 443-458. Retrieved August 26, 2020, from After revisiting these sessions, Grinberg gave a rational explanation to what he  observed, creating the Syntergic Theory, where he proposed the existence of a continuum of spatial energy of which the common human only perceives a portion from  a basic spatial organization (matrix, lattice), on which the neural plane of the shaman would act, producing physical alterations of this space initially detected in the real world as elementary particles and as  complex distortions (visual, auditory perceptual realities, objects, creation of experience, etc.): with field neuronal interactions  with levels  of the lattice, in which each floor represents a different level of consciousness (auditory, visual), with the sum of activities at the highest  level, contradicting the current concepts of reality, envisioning the tremendous capacity of the human brain as a continuum facilitated by Taoist meditation by enhancing all  of our physiological systems, being the initiate  able to observe even his own brain activity (dipasha technique), visualizing  diseased tissues calmly (brain waves at 10 cycles per second), promising the synergistic theory to be the theoretical framework for the functioning of consciousness and his levels, explaining the creation of perception.Suddenly Jacobo dissapeared in  1994.


Sunday, August 09, 2020


Taken from Nature


According to several ecologists, ,  animals that populated the Earth before humans, had a prolonged contact with viruses establishing between them an adaptation or peaceful coexistence thanks to adaptation of their genetic and immune systems. When in recent decades, humans began to ruthlessly predate and pollute nature and take the lives of thousands of animals, viruses adapted to them were forced to seek other bodily habitats to survive, leading to: 1) Terrifying pandemics in humans until they manage to adapt their genetic and immune systems to viruses, establishing an adaptation or peaceful coexistence with viruses, hoping that : 2) With the help of science we will understand the reason for being of the viruses and the characteristics of animal virus reservoirs. In this sense, initially orienting oneself  towards the study of the genomes of bats is an illuminating idea, since certain groups of viruses that cause great morbidity and mortality are housed in the Ferreungulata group of mammals, which includes: dogs, cats, seals , pangolins, bats, etc. An idea concretized in the formation of the Bat1K consortium, a global group of scientists, committed to sequencing the genomes of 1,421 species of bats, of which 6 have been precisely sequenced so far, thanks to the tenacious work of David Jebb (Center for Systems Biology Dresden/Max Planck Inst. for Cell Biology and Genetics), Emma Teeling (Biologist/University College Dublin), Sonja Vernes (Neurogenetics of Vocal Communication/Max Planck Institute), and others, who using the new technology DRESDEN-Concept Genome Center Max Planck Institute/Germany), , sequenced the DNA of 6 species of bats, identifying their genes with accuracy (98%), in the correct order, with an unprecedented quality, showing for the first time, the encoded genetic material of bats, , their unique adaptations: ability to fly, use sound to move effortlessly in the dark, survive and tolerate deadly diseases, extend their lifespan and resist cancer, being identified  genomic changes associated with unique adaptations, looking for genetic differences between bats and other mammals, genetic regions that evolved differently in bats, with loss or gain of genes, changes in auditory genes, to improve their echolocation, to hunt and navigate in the dark, antiviral gene expansions, immune gene selections and loss of inflammation genes, endowing bats with an exceptional immunity to tolerate viruses, apart from the finding of fossilized viruses in their genomes. An intense work,  in which Teely and collaborators took blood samples from bats at different stages of their lives by placing a chip on their legs, in search of vital biomarkers, performing various molecular tests finding that: 1) unlike most mammals where their telomeres shorten after each cell division, triggering the need to die by becoming senescent cells, which no longer replicate and attract healthy cells by aging them, the telomeres of bats do not shorten with age, when cells divide and they also do not have cancer, finding that 2 of their genes: TX and ATM, continue to evolve. 2)  compared to the mitochondrial theory that maintains that free radicals have the ability to destroy mitochondria, in bats, their mitochondria develop mechanisms that limit the deleterious effects of free radicals. 3) The sequencing of all blood transcriptomes revealed changes that keep their DNA current as they age, as well as an increase in their ability to repair their DNAs. 4) While in other mammals their microbiomes change for the worse, the bat microbiome does not change with age 5) Bats, present an active autophagy, capable of removing protein and cellular damage. 6) They maintain a balanced immune system, aimed at maintaining homeostasis, canceling the inflammation produced by their high metabolism, demonstrated by their high production of TNF and IL, solidifying the use in humans of anti-inflammatory drugs in Covid-19 disease, according to the stage of disease.


Tuesday, July 21, 2020



According to Archimedes of Syracuse (287 BC-212 BC), the Greek Aristarchus of Samos (310 BC-230 BC), after calculating with the help of the Pythagorean theorem (569 BC-475 BC), inferred that the Sun was 20 times (currently: 400 times), larger than Earth and therefore smaller planets like Earth had to revolve around the Sun.  Copernicus (1473-1543), would hold the same, albeit with more elaborate theoretical foundations, when addressing the relations between the Earth and the Sun, maintaining that the first rotates around the Sun, by means of movements of rotation, translation and declination, which explained the seasons and the equinoxes. Later, Galileo (1564-1642), with arguments of the causes of the tides, sunspots, rotation of Venus around the Sun, and the presence of satellites rotating around Jupiter -and not around Earth- would solidify the Heliocentric theory. After the discovery of the Milky Way (1610), by Galileo with a simple telescope, cosmology was advanced, although it would take 300 years to stop thinking that our Milky Way, containing our Solar System at its center, was the only one galaxy of our visible universe. In 1920, Edwin Hubble took a Copernican turn to cosmological studies, showing ¡oh, surprise!  that our universe contained many galaxies, therefore being larger and continuing to expand. With more powerful telescopes, Hubble, was locating the position of various galaxies, consolidating a more accurate and detailed cosmic mapping. Noting that the spectral lines of the nebulae were deviated towards the red color (redshift), he understood that most galaxies were expanding. Hubble then said that galaxies were moving away from us at a speed proportional to the distance that separates us from them. The galaxies discovered in the following years allowed the construction of larger maps of the universe, although still imperfect, creating the need to make more discoveries, to create cosmological maps capable of pinpointing the place in the cosmos where our solar system and planet are located.  The most recent cosmological findings related especially to galactic superclusters, are truly disruptive and could determine the awarding of future Nobel Prizes to scientists who generate new knowledge in this area. It has recently been published in the Astrophysical Journal, 2020; 897; 133 (2)., the article: Cosmicflows-3. The South Pole Wall, by Daniel Pomarede (Paris-Saclay University), R. Brent Tully (University of Hawaii) and collaborators, reporting the discovery of a gigantic galactic supercluster, behind the south pole of our visible universe, with views captured by the telescope: NASA Spitzer Space, showing a large-scale structure adjacent to a galactic dust-obscured area, opposite to the Shapley supercluster, behind the Chameleon Nebula, along a strip of ~ 1.37 millions of light years from the Perseus constellation to the Apus constellation in the southern hemisphere. The authors measured the distances of thousands of galaxies in strips of 600 million light years, based on observations of the speeds of   galaxies, as they deviated from those inferred for universal expansion, used to model velocities and 3-D field densities, with adjustments to satisfy the data and the Standard Model of Cosmology, working with topological models that contained filaments, knots, voids and surfaces, forming an interconnected network (cosmic web), with scales of 1 billion light years (20,000km/sec), determining for the first time, the almost exact position of our planet in the visible Universe. Astronomers use the term "redshift," to refer to: a) a referential measure to establish relative distances in the universe, which allows them to discriminate between the motion caused by cosmic expansion, and those caused by gravity  and b) to determine the cosmic flows  (travel paths of stars and galaxies), promoted by universal expansive forces and those induced by gravitational irregularities. According to several authors, the cosmos is flooded by microwave radiation with an average temperature of 2.7 degrees Kelvin, since the start of the Big Bang, being higher in certain sectors, hinting that these microwave strips would be the routes by which the galaxies including our Local Group, travel  in the direction -apparently determined- of the Great Attractor, although according to Tully, the movement towards this super-attractor would not be determined, but would be the result of the confluence of forces of the South Pole Wall and other superclusters, dark matter and gravity. From the South Pole Wall, we will only say that its dimensions are comparable to that of other superclusters (Great Wall, Sloan Great Wall, etc). By forming conglomerate of galaxies (clusters or superclusters), it is noticeable on a large scale, that they are connected to each other by interlocking filament chains producing intricate galactic topological and geometric shapes, including dark and empty spaces, spanning billions of light years. More close to us,  the Milky Way formed  by  small clusters of galaxies (Local Group), appears located near the Virgo cluster, which together with other galaxies are part of a gigantic supercluster: Laniakea, the same that is heading faster than established by Hubble's law, towards the Great Attractor, located just beyond the Centaurus Constellation.

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Sunday, July 12, 2020



Although Kathie Mack, a professor of physics at North Carolina State University (USA) and  Simons Fellow of the Perimeter Institute for Theoretical Physics (Waterloo/Canada), has studied Physics,  over time she has acquired an expanded vision thanks to added knowledge of Astrophysics and Cosmology, which allow her to have a perspective of a  full  universe. from the beginning to the end, on small and large scales, studying their evolution over time, finally being able to predict that  the end of the universe will be preceded by a continuous expansion of the universe where galaxies will  be separated more and more from each other, leaving spaces between them getting bigger, foreseeing a slowing down of stars  and galaxies  formation, generating isolation between galaxies. The local group (Milky Way, Andromeda and others), that we inhabit will stop producing stars, the rest of  them falling into black holes that  will evaporate, leaving as their only trace a cold, empty and dark universe with strange particles and radiation. Shortly, before the extinction of the universe and according to an important group of scientists, a terrific   process called : heath death will occur,  associated to an eternal accelerated expansion  of our universe, while others propose a Big Crunch or  a state of  slow, infinite expansion. At the moment, dark energy and the cosmological constant, keep the possibility of a Big Crunch away, because according to Kathie Mack, the result of the action of gravity that holds galaxies together and the dark energy (produced in certain  high density parts of  dark matter), that separates galaxies, will be one that will favor largely to dark energy, predictions almost confirmed by the discoveries of the Wilkinson Microwave Anysotropy Probe (WMAP/1998), which validated the power of dark energy in processes of separation of  galaxies. Because dark matter does not emit electromagnetic radiation and does not interact with light, this matter appears invisible, and we can pass through it. Inside this matter, electrostatic repulsion processes are carried out between particles, generating dark energy which allow the rotation of galaxies, a feat impossible to be done only by gravity. As dark energy is able to increase its density over time, it is capable of rapidly destroying the universe in a finite time, so dark energy is predicted to overcome the power of gravity that unites galaxies, being able to produce major cosmic damage. Another theoretical proposal of extinction of the Universe is the vacumm decay, for  not  being the universe completely stable, since it is known that laws of physics can change with temperature or environmental energy, the occurrence of particle collisions at high energies,  where  laws of physics are slightly different, just like in the early universe, where after a few transitional processes   emerged  a universe  that possessed electromagnetism, weak and strong nuclear forces and gravity. That is to say,  any cosmic disturbance could alter the physical laws that we know, resulting  that, at the point in space where these changes begin to occur, it will be possible to observe a true vacuum bubble that, when expanding at the speed of light, through the universe, it will destroy instantly and painlessly, everything without violating any fundamental principle of physics. At the moment, the energy  produced by  dark matter is explained by the collision of particles with each other, creating high-energy particles, in areas where dark matter is more concentrated, that energy power being directly proportional to the square of its density (at higher density, more power), being more concentrated in dark matter halos, where large particle collisions occur, in the very center of galaxies. Such halos would have formed the first galaxies, and if heat is produced in the center of them, it would push the gas out of the halos, slowing down after the formation of the first galaxies. Kathie Mack argues that counteracting gravity with dark energy will bring at some point, the end of our universe, annihilating in an instant any vestige of existing intelligent civilization turning everything built by humans into nothing, in a few seconds. If other civilizations exist in the Universe, perhaps they would be interested in maintaining a certain degree of status quo of the universe and its laws so as not to accelerate processes of destruction, so they could be watching the universe. On the other hand, if the entire cosmos died our lives would have made no sense, says Kathie. However, in the face of this almost deterministic extinction of the Universe, there could be another  -albeit minimal  possibility- of migrating to a nascent or already built universes, by means of teleportation processes of our bodies (transformed into particles, to be reconstructed later) or traveling by wormholes or black holes

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Thursday, June 18, 2020



I-A vast number of scientists agree that the predation of nature started with the industrial age and was facilitated by contemporary globalization (deforestation of forests and jungles, pollution of the sea, corruption of the land by mining waste, of space with space debris, emergence of holes in the ozone layer, darkening of our skies by industrial smog, global warming with lysis of glaciers, extinction of certain animal species), has changed nature, making it inhospitable. So, soon after the Covid-19 pandemic started, it was easy to see countless dolphins, pelicans and other birds, on the coasts of quarantined countries, a sign of the ongoing misfortune (they came for food and to recover their inheritances). It is that, for thousands of years, the corporality of animals and the structure of vegetables was the first defensive mattress against fierce viral attacks. The viruses attacked the animals that populated the earth before humans because their complex bodies allowed them to reproduce. After a prolonged fight, the animals generated their own defenses and varied natural immune strategies, establishing a mutually beneficial virus-animal coexistence. When time passed, the viruses realized that the animals were decimated and cornered, they opted for the obvious: to replace animals   with the increasingly numerous humans, lately living in metropolises with high population density. While SARS (2002) and MERS (2012) were exploratory coronaviruses, Covid-19, like others in progress, with more confidence and better strategies are here to stay. II-In the face of the Covid-19 pandemic and others to come, obvious proposals emerge: a) The first is to convene a global forum in which, at the same time that we discuss preventive proposals to improve global human health, we also take into account the entire health of planet Earth, which we should see as a properly shared, distributed and cared for whole (Gaia hypothesis), -hypothesis-wikipedia.pdf in which all human activities should be seen in a different, healthier, more ecological way, starting with mass wind and solar energy, instead of oil-derived pollutants, preserving world forests and jungles, promote democratic coexistence of all human races and minority groups, compromise and harmony with all plant animal species, but also with bacteria and viruses, in such a way that all beings alive -not only humans- will be the end and not the means. III. Preventing and fighting the pandemics to come also implies giving answers to unresolved questions. Regarding viruses: a) Why are viruses selectively attracted to cellular genomes? What does it mean for a virus's RNA to perfectly match the DNA of a cell and reproduce? A phenomenon that happens to parts that were once a whole. b) Where do viruses come from? Are they incomplete remains of dead animals or vegetables? Recycled paleofossils? If so, the cremation of all living dead beings could be a solution. c) The presence of a genome within viruses makes them computable, that is, predictable, with respect to their actions. If so, then the number of its potential mutations and even the severity of its infectivity could be calculated. d) The permanence of viruses in the animal and human genome helped to evolve the latter? Perhaps, by finding answers to these questions, we can take leaps and bounds in this regard and not just be relying on vaccines. We need scientific dissertations and reflections, with perspective.

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Friday, May 29, 2020

Bad controlled diabetes and brain

In some way, the type of food eaten by humans is related to the functions of our organs, our general corporality and our state of mind. According to the Australian researcher Felice Jacka,, the children (1 1/2-5 years), of pregnant women who consumed junk food (high fat and abundant sugar),  turned out to be more aggressive, prone to tantrums and at the same time more fearful. However, the type of food eaten is not only related to the mentioned changes. Recently, the researcher Lilianne R. Mujica-Parodi (Stony Brooks Universityy/Lab for Computational Neurodiagnostics) and collaborators, investigated whether the type of  ingested diet was capable of optimally maintaining the functionality of the brain neural networks, improving neural functional communication, when the dietary fuel (usually glucose) is exchanged for ketones, being recognized  ever since: the optimal functionality of neural networks, as a biomarker of brain aging. Previous studies have shown that the destabilization of the brain neural networks conditions a decrease in brain activity and cognitive acuity, effect being noted from the age of 47, with more rapid destabilization from the age of 60. DOI: https: // 10.1016 / S2213-8587 (13) 70192-X. In the case of type 2 diabetics (DM2), with insulin resistance, the possibility has been raised that glucose elevation (poorly controlled), is an early risk factor for dementia in adulthood due to rapid decrease in memory, reasoning and cognition doi: 10.1212 / WNL.0b013e3181f25f06, so some researchers think that dementia might even be a metabolic disease. To demonstrate  the influence of diet type on optimal maintenance of the functionality of brain neural networks required using large-scale functional magnetic resonance datasets and scanning a cohort provided with a standard diet, night fast, and ketogenic diet and another independent cohort, with overnight fasting before and after administration of an exogenous bolus of ketone ester (D-β-hydroxybutyrate), equal in calories to that provided by a type of diet based   in glucose. In this study, the functionality of human brain neural networks was destabilized by glucose and stabilized by ketone, regardless of whether ketosis was achieved with a ketogenic diet or exogenous ketone esters, the results suggesting that destabilization of neural networks  may reflect early signs of hypometabolism associated with dementia due to persistent glucose elevation, as occurs in uncontrolled DM2, indicating that the destabilization of neural networks could be an adaptive response of the brain in order to conserve energy in the face of scarcity of resources. This study clarifies how diet influences brain aging, explaining how insulin resistance in poorly controlled diabetics accelerates the progression of cognitive decline as people age. A deterioration possibly related to hypometabolism of brain glucose, reversed by another type of ketone-based diet, which by increasing the available energy, prevent early brain aging. Young people who eat mainly junk food could be another group of beneficiaries, provided they switch to diets containing polyunsaturated fatty acids: fat from certain fish, vegetable oils, nuts, seeds, etc.

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Friday, May 22, 2020



After reviewing several papers, watching national and international videoconferences and scrutinizing ideas related to the clinic and treatment of the Covid-19 epidemic, we were left with some clear things, which in descending order of importance are: 1) Epidemiological measures. 2) Immunity: anti-virus vaccines, infusion of hyperimmune plasmas. of convalescent human to certain coronavirus infected people.  3) Knowledge (even scarce) of the structure and function of viruses 4) Molecular tests and mathematical calculations 5) Investigations carried out in the same field of events. We will comment on the first 2 items. I) Knowing that viral pandemics are directly related to the increase in population density ( -decrease it, is essential- although the effectiveness of this measure varies according to the economic and educational condition of each country. In developing nations such as Peru, the success of social confinement is hampered by the aforementioned inequalities, especially by the urgent daily economic needs. Although in Peru, a national health emergency law was established early ( 2020-sa-1863981-2 /), that established social isolation, its compliance was strictly observed in certain districts of Lima and the rest of the country, more economically fluent. These, having housed the first imported cases, showed a moderate rise in the epidemiological curve, which has currently slowed down, anticipating that this first group would begin to travel from the descending part of the curve since mid-June. The same is not happening in the poorest and most densely populated districts of Lima and some departments of Peru (70% of the Peruvian population) -the-new-concentration-points-of-the-covid-19-according-to-the-heat-map, whose cases began to increase 3 weeks after those of the first group, originating because of the above :a steepening and prolongation of the ascending part of the curve that, as some  mathematicians explain, is destined to undergo a stop in the coming weeks, and after crossing the plateau, begin a general decline, not without some obstacles generated in markets (https: // management. pe / peru / politics / coronavirus-peru-10-markets-in-lima-identified-as-foci-of-contagion-of-covid-19-nndc-news /), buses, pharmacies, building elevators multi-family, etc). II) Immunity: a) Taking into account that the Covid-19 virus produces an asymptomatic clinical course in 80% of those infected ( -confirmed-by-coronavirus-cov19-amount-to-104-020-in-the-peru-reported-n-106 (usually under 50 years), it is concluded that this process -luck of natural selection- tolerates the strongest and eliminates the weakest. Rethinking the positive aspects of the aforementioned process has applications in the current pandemic - which will be repeated in the coming years – being the fundamental thing  to ensure that our immune system adapts to that of the virus, establishing a  coexistence human-virus,  subject to a single rule, except for responsibilities to the virus, if our immune system is weakened b) Taking into account  that prophylactic and therapeutic medical treatment lacks consensus and is mostly symptomatic, at the moment the most solid therapy against coronavirus is the creation of a vaccine  under the rules of acquired immunity. Vaccine production currently suffers from two problems: delay in producing it and considering that efficacy of  dead or attenuated  cannot be predicted with certainty. According to the expert: Christine Stabell Benn, the use of live antigens, banned by the WHO, give protection for 15 years and are 96% effective. In our country a vaccine is being produced with protein extracts from the virus crown (dead virus) against-the-covid-19-news-1263525
c) Type of problems that induces us to locate the infusion of hyperimmune plasma from convalescent humans: secondly, by being able to reverse the severity of the viral symptom-symptomatology, in 24 hours. Any level III hospital is able to prepare this plasma using a simple method, provided you have informed consent, the blood fractionation machine and a trained hematologist or pathologist. feel-almost-magically-very-well/Q52HIGGIYNAGFCQPTBIM37YEJQ/ d) On the other hand, some scientists argue that attenuated BCG vaccination -vaccine-to-fight-coronavirus.html provides protection not only against tuberculosis but also against viruses, fungi and some types of cancer. e) We need to know more about the virus. For now and according to Luc Montagnier, Nobel Prize in Medicine, some antigenic sequences of the current coronavirus have been artificially replaced by others containing HIV RNA, supposedly made in a laboratory of China, processes that would have endowed the coronavirus with a greater infectivity. Fortunately and according to Montagnier himself, nature only supports a certain order where this bizarre virus does not fit, so the self-elimination of HIV sequences, are almost certain, making the virus less  aggressive, thereby ending the pandemic.

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